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The most common use of anabolic steroids is to boost sports performance, but they can be a The key effects of anabolic steroids include: . Are steroids legal?16 Mar 2005 Legal prosecution can be a serious side effect of illicit steroid use. Under federal law, first-time simple possession of anabolic steroids carries a
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Activated GSK3-β phosphorylates several members of the NFAT family, which promotes their translocation from nucleus to cytoplasm. Akt phosphorylates and inhibits GSK3-β, which increases the residence of NFAT in the nucleus. Moreover, Akt has the ability to phosphorylate mTOR, another downstream target of the PI3K/Akt pathway. In muscle cells, protein synthesis is highly regulated by mTOR, which stimulates protein translation and ribosome biosynthesis [124 ]. The mTOR lies upstream of critical translation regulators such as the 40S ribosomal protein S6 kinase 1 (S6K1) and the eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). Activation of the mTOR pathway is a critical step to induce cardiac hypertrophy by testosterone in vitro [15 ].


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